Ara h 2 is the dominant peanut allergen despite similarities with Ara h 6
نویسندگان
چکیده
منابع مشابه
Ara h 6 complements Ara h 2 as an important marker for IgE reactivity to peanut
The similarities of two major peanut allergens, Ara h 2 and Ara h 6, in molecular size, amino acid sequence, and structure have made it difficult to obtain natural Ara h 6 free of Ara h 2. The objectives of this study were to purify natural Ara h 6 that is essentially free of Ara h 2 and to compare its IgE reactivity and potency in histamine release assays to Ara h 2. Sodium dodecyl sulfate-pol...
متن کاملIgE cross-reactivity between the major peanut allergen Ara h 2 and the non-homologous allergens Ara h 1 and Ara h 3
BACKGROUND Ara h 1, a vicilin; Ara h 2, a 2S albumin; and Ara h 3, a legumin, are major peanut allergens. Ara h 2 is an important predictor of clinical reactivity to peanut, but cosensitization to all 3 allergens is correlated with the severity of patients' symptoms. OBJECTIVE We investigated whether cosensitization to these 3 allergens is caused by IgE cross-reactivity, despite the fact that...
متن کاملPeanut allergen (Ara h 1) detection in foods containing chocolate.
Inadvertent exposure to peanut in foods poses health risks for peanut-allergic individuals that can be reduced by improving detection systems for allergen contaminants in food products and manufacturing processes. Detection of peanut in chocolate has been especially difficult. We report the optimization of conditions for measuring a major peanut allergen, Ara h 1, in chocolate with the use of a...
متن کاملImportance of Ara h 6 in peanut allergy diagnosis
Results Twenty-two children (median age: 6.63 y.o.; IQR: 5.22-10.12) were classified as allergic in the basis of at least two convincing clinical reactions upon ingestion of PNT in the last two years. Sixty-nine children (median age: 8.01 y.o.; IQR: 6.01-11.27) were classified as tolerant on the basis of regular consumption of PNT. Positive SPT with commercial PNT extract was found in 86% of th...
متن کاملRecombinant peanut allergen Ara h I expression and IgE binding in patients with peanut hypersensitivity.
Peanut allergy is a significant health problem because of the frequency, the potential severity, and the chronicity of the allergic sensitivity. Serum IgE from patients with documented peanut hypersensitivity reactions and a peanut cDNA expression library were used to identify clones that encode peanut allergens. One of the major peanut allergens, Ara h I, was selected from these clones using A...
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ژورنال
عنوان ژورنال: Journal of Allergy and Clinical Immunology
سال: 2020
ISSN: 0091-6749
DOI: 10.1016/j.jaci.2020.03.026